标题：Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis
作者：Xu, J. M.; Song, X.; Gao, F.; Wang, R.
作者机构：[Xu, J. M.] Shandong Univ, Coll Med, Jinan 250100, Shandong, Peoples R China.; [Xu, J. M.] Dong E Hosp, Dept Nephrol, Dong E, Shandong, Peoples R Ch 更多
通讯作者地址：[Wang, R]Shandong Univ, Shandong Prov Hosp, Dept Nephrol, Jinan 250100, Shandong, Peoples R China.
来源：GENETICS AND MOLECULAR RESEARCH
关键词：A1166C; Angiotensin II type 1 receptor; IgA nephropathy; Gene; polymorphism; Meta-analysis
摘要：Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles were identified in the PubMed, Google Scholar, and China National Knowledge Infrastructure databases, and after selection, five eligible studies were included. Statistical analyses were carried out using Stata 12.0, combining data from all the relevant studies. The pooled odds ratios (ORs) regarding the association between the AGTR1 A1166C polymorphism and IgAN risk were not statistically significant [A vs C: OR = 0.64, 95% confidence interval (CI) = 0.24-1.68; AA vs AC+ CC: OR = 1.02, 95% CI = 0.74-1.39; CC vs AC+ AA: OR = 1.20, 95% CI = 0.48-2.98; AC vs AA+CC: OR = 0.96, 95% CI = 0.70-1.31]. In conclusion, the AGTR1 gene A1166C polymorphism may not be correlated with IgAN susceptibility. However, further studies should be performed to confirm this finding.