标题：Aberrant BLID expression is associated with breast cancer progression
作者机构：[Li, X] Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road No.107, Jinan 250012, China;[ Su, P] Department of Pathology, 更多
通讯作者地址：[Yang, QF]Shandong Univ, Qilu Hosp, Dept Breast Surg, Wenhua Xi Rd 107, Jinan 250012, Peoples R China.
来源：Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine
摘要：In our previous study, we have found that BH3-like motif containing, cell death inducer (BLID) was a tumor suppressor in breast cancer, and its downregulation was correlated with both poor disease-free and overall survival. In the present study, we aimed to explore the possible role of BLID in breast cancer progression. We found that BLID was strongly expressed in all normal breast tissues, and it became lower and wreaker gradually in the progression from normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), and DCIS (ductal carcinoma in situ) to breast cancer. Statistical analysis demonstrated significant different BLID expressions between proliferative and cancerous breast lesions. Our data suggested that loss of BLID may contribute to the progression of intraductal proliferation lesions to breast cancer. Our finding gives a new clue that BLID might be a potential indicator for progression of breast cancer in the future.