标题：MicroRNAs in the pathogenesis of systemic lupus erythematosus
作者：Ma, Xiaochun; Liu, Qiji
作者机构：[Liu, Qiji] Shandong Univ, Minist Educ, Key Lab Expt Teratol, Sch Med, Jinan 250012, Shandong, Peoples R China.; Shandong Univ, Dept Med Genet, Sch 更多
通讯作者地址：[Liu, QJ]Shandong Univ, Minist Educ, Key Lab Expt Teratol, Sch Med, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
关键词：estrogen; interferon; methylation; microRNA; regulatory T-cell; systemic; lupus erythematosus
摘要：Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease, characterized by the production of autoantibodies against multiple organs. MicroRNAs (miRNAs) are non-coding, single-stranded small RNAs that post-transcriptionally regulate gene expression. Evidence is accumulating that miRNAs play a pivotal role in the pathogenesis of SLE. This article reviews the pertinent publications (searched from the PubMed database) involving the mechanisms of actions of miRNA associated with the pathogenesis of SLE. The search of related literature was extended as far back as 1979. In this mini-review we first introduce the miRNAs briefly and later discuss their regulatory roles in the DNA methylation pathway, type I interferon pathway, estrogen and regulatory T-cells in the pathogenesis of SLE.