标题：In vivo metabolism study of bergenin in rats by HPLC-QTOF mass spectrometry
作者机构：[Song, H] Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China, Institute of Pharmacology, Medicin 更多
通讯作者地址：[Guo, RC]Shandong Univ, Inst Clin Pharmacol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
来源：Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences
摘要：Bergenin is the major component of Ardisia creanta sims and Rodgersia sambucifolia hemsl with many biological activities. Although bergenin has been used to treat human diseases in China for man years, there is no report regarding its metabolism. This is the first report to separate and identify the metabolites of bergenin in vivo. In the study, HPLC/Q-TOF-MS/MS was used to investigate the metabolites of bergenin in vivo by analyzing the rat body fluid and feces samples. Three metabolites of bergenin were finally identified by the TIC chromatograms, and the structures were also confirmed by their MS2 spectra.