标题：Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats
作者：Liu, Yuan; Liu, Dexiang; Xu, Jingjing; Jiang, Hong; Pan, Fang
作者机构：[Liu, Yuan; Liu, Dexiang; Xu, Jingjing; Jiang, Hong; Pan, Fang] Shandong Univ, Sch Med, Dept Med Psychol, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peo 更多
通讯作者地址：[Pan, F]Shandong Univ, Sch Med, Dept Med Psychol, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
关键词：5-HT1A receptor; miRNA-135a; miRNA-16; post-traumatic stress disorder;; vulnerability
摘要：Early-life stress increases susceptibility to post-traumatic stress disorders (PTSD), in which the dysfunction of 5-hydroxytryptamine plays an important role. miRNA-135a in the prefrontal cortex (PFC) and miRNA-16 in the hippocampus (HIP) are closely related to the 5-HT neurotransmitter system. Here, we investigated behavior, miRNA-135a in the PFC, miRNA-16 in the HIP, and 5-HT1AR expression in both brain regions in adolescent and adult rats that were exposed to inescapable stress during their adolescence. Paroxetine hydrochloride and corticotropin-releasing factor antagonist (CP-154,526) were used as intervening measures. Our study demonstrated that early adolescent stress induced anxiety-like behaviors and spatial memory damage, a reduction in miRNA-135a expression was associated with increased 5-HT1AR expression in PFC, and increased miRNA-16 expression in the HIP of stressed rats. Drug treatments alleviated behaviors and reversed the miRNA-135a, miRNA-16, and 5-HT1AR expression in stressed rats.