标题：Synthesis and in vivo Anti-inflammatory Evaluation of Piperazine Derivatives Containing 1,4-Benzodioxan Moiety
作者：Liu, Zhi-Ping; Gong, Chang-Da; Xie, Long-Yan; Du, Xiu-Li; Li, Yang; Qin, Jie
作者机构：[Liu, Zhi-Ping] Pingdingshan Univ, Sch Med, Pingdingshan 467000, Peoples R China.; [Gong, Chang-Da; Xie, Long-Yan; Du, Xiu-Li; Li, Yang; Qin, Jie] S 更多
通讯作者地址：[Qin, J]Shandong Univ Technol, Sch Life Sci, Zibo 255049, Peoples R China.
来源：ACTA CHIMICA SLOVENICA
关键词：Piperazine; 1,4-benzodioxan; crystal structure; anti-inflammatory; activity
摘要：Six piperazine derivatives 6a-f containing 1,4-benzodioxan moiety have been synthesized and characterized by H-1 NMR, ESI-MS and elemental analysis. The structure of 6d was further confirmed by single crystal X-ray diffraction. All these novel compounds were screened for their in vivo anti-inflammatory activity employing classical para-xylene-induced mice ear-swelling model. The results revealed that most of the target compounds showed significant anti-inflammatory activities, especially compound 6a with ortho-substituted methoxy group on the phenylpiperazine ring exhibited the best activity among the designed compounds.