标题:Synthesis and in vivo Anti-inflammatory Evaluation of Piperazine Derivatives Containing 1,4-Benzodioxan Moiety
作者:Liu, Zhi-Ping; Gong, Chang-Da; Xie, Long-Yan; Du, Xiu-Li; Li, Yang; Qin, Jie
作者机构:[Liu, Zhi-Ping] Pingdingshan Univ, Sch Med, Pingdingshan 467000, Peoples R China.; [Gong, Chang-Da; Xie, Long-Yan; Du, Xiu-Li; Li, Yang; Qin, Jie] S 更多
通讯作者:Qin, J
通讯作者地址:[Qin, J]Shandong Univ Technol, Sch Life Sci, Zibo 255049, Peoples R China.
来源:ACTA CHIMICA SLOVENICA
出版年:2019
卷:66
期:2
页码:421-426
DOI:10.17344/acsi.2018.4887
关键词:Piperazine; 1,4-benzodioxan; crystal structure; anti-inflammatory; activity
摘要:Six piperazine derivatives 6a-f containing 1,4-benzodioxan moiety have been synthesized and characterized by H-1 NMR, ESI-MS and elemental analysis. The structure of 6d was further confirmed by single crystal X-ray diffraction. All these novel compounds were screened for their in vivo anti-inflammatory activity employing classical para-xylene-induced mice ear-swelling model. The results revealed that most of the target compounds showed significant anti-inflammatory activities, especially compound 6a with ortho-substituted methoxy group on the phenylpiperazine ring exhibited the best activity among the designed compounds.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068556522&doi=10.17344%2facsi.2018.4887&partnerID=40&md5=19c730cf94816b1d98633d08a687e47d
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