标题：Stimuli-responsive polymeric micelles for the delivery of paclitaxel
作者：Yang H.; Khan A.R.; Liu M.; Fu M.; Ji J.; Chi L.; Zhai G.
作者机构：[Yang, H] Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong Univers 更多
通讯作者地址：[Zhai, G] Department of Pharmaceutics, School of Pharmaceutical Sciences, ShandongUniversity, 44 WenhuaXilu, China;
来源：Journal of Drug Delivery Science and Technology
关键词：Paclitaxel; Polymeric micelles; Stimuli-responsive; Tumor targeting
摘要：Paclitaxel is an anti-tumor drug that is effective in the treatment of various tumors, but its applications are limited due to its poor water solubility, short biological half-life and severe side effects. A tumor has many features that are different from normal tissues, such as mild acidity, strong reducing environment and over-expressed certain enzymes. Many smart micelles sensitive to internal or external stimuli have been developed that could realize the release of drug at tumor site. In addition, micelles could improve the aqueous solubility, potentiate therapeutic efficacy and, reduce the side effects of drugs to the normal tissues. This review summarizes recent studies on stimuli-responsive micelles for the delivery of paclitaxel and their potential applications in cancer therapy. © 2020 Elsevier B.V.