标题:Facile Enzymatic Synthesis of Phosphorylated Ketopentoses
作者:Wen, Liuqing; Huang, Kenneth; Liu, Yunpeng; Wang, Peng George
作者机构:[Wen, Liuqing; Huang, Kenneth; Liu, Yunpeng; Wang, Peng George] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA.; [Liu, Yunpeng; Wang, Peng Geo 更多
通讯作者:Liu, Yunpeng
通讯作者地址:[Liu, YP; Wang, PG]Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA;[Liu, YP; Wang, PG]Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, People 更多
来源:ACS CATALYSIS
出版年:2016
卷:6
期:3
页码:1649-1654
DOI:10.1021/acscatal.5b02234
关键词:biocatalysis; enzymatic synthesis; phosphorylated ketopentoses; one-pot; reactions; silver nitrate precipitation
摘要:An efficient and convenient platform for the facile synthesis of phosphorylated ketoses is described. All. eight phosphorylated ketopentoses were produced using this platform starting from two common and inexpensive aldoses (D-xylose and L-arabinose) in more than 84% isolated yield (gram scale). In this method, reversible conversions (isomerization or epimerization) were accurately controlled toward the formation of desired ketose phosphates by targeted phosphorylation reactions catalyzed by substrate-specific kinases. The byproducts were selectively removed by silver nitrate precipitation avoiding the tedious and time-consuming separation of sugar phosphate from adenosine phosphates (ATP and ADP). Moreover, the described strategy can be expanded for the synthesis of other sugar phosphates.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:10
Scopus被引频次:12
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960093418&doi=10.1021%2facscatal.5b02234&partnerID=40&md5=f2410855101ea01ed3bf611c2f46452d
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