标题：The absence of TERT promoter mutations in primary gastric cancer
作者机构：[Liu, T] Department of Microbiology, School of Medicine and Second Hospital, Shandong University, Jinan, China, Key Laboratory for Experimental Terato 更多
通讯作者地址：[Jia, JH]Shandong Univ, Dept Microbiol, Sch Med, Jinan 250012, Peoples R China.
来源：Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function
摘要：Dear Editor, Telomerase activation through the induction of telomerase reverse transcriptase (TERT) is an essential step in malignant transformation, and widely occurs in various types of cancer including gastric cancer (Daniel et al., 2012). The primary determinant for the cancer-specific telomerase activation is the transcriptional de-repression of the TERT gene (Daniel et al., 2012). The regulatory mechanism underlying TERT transcription in oncogenesis has been extensively studied for many years, but remains incompletely understood. The somatic TERT promoter mutations named C228T and C250T have recently been identified in various human malignancies, and these mutations create de novo ETS1 binding motifs that stimulate TERT transcription and enhance telomerase activity (Horn et al., 2013; Huang et al., 2013). Huang et al. found the C228T mutation in 1 of 12 gastric cancer cell lines, indicating the presence of this genetic event in gastric cancer (Huang et al., 2013). However, it is currently unclear whether the TERT promoter mutation also occurs in primary gastric cancer.