标题:Isolation of 11,12-seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain
作者:Shi, Yanrong; Zhang, Juanli; Tian, Xiuyu; Wu, Xingkang; Li, Tianhong; Lu, Chunhua; Shen, Yuemao
作者机构:[Shi, Yanrong; Tian, Xiuyu; Wu, Xingkang; Li, Tianhong; Lu, Chunhua; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 更多
通讯作者:Shen, YM;Shen, YM
通讯作者地址:[Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China;[Shen, YM]Acad 更多
来源:ORGANIC LETTERS
出版年:2019
卷:21
期:4
页码:900-903
DOI:10.1021/acs.orglett.8b03792
摘要:This study reported the isolation and characterization of 11 rifamycin congeners including six new ones (1-6) from the agar fermentation extract of Amycolatopsis mediterranei S699. Compounds 1 and 2 are rifamycin glycosides named as rifamycinosides A and B, respectively. Their polyketide skeleton represents a novel cleavage pattern of the rifamycin ansa chain. Compounds 6 and 8 showed potential T3SS inhibitory activity, and 6 induced G2/M phase arrest and caused DNA damage in HCT116 cells.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061561732&doi=10.1021%2facs.orglett.8b03792&partnerID=40&md5=742d66349bbf1a9716924eadccd9d6d7
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