标题:Targeting phosphatidylcholine-specific phospholipase C for atherogenesis therapy.
作者:Li H;Zhang L;Yin D;Zhang Y;Miao J
作者机构:[Li, H] Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology amd School of Life Science, S 更多
通讯作者:Miao, JY
通讯作者地址:[Miao, JY]Shandong Univ, Shandong Prov Key Lab Anim Cells & Dev Biol, Inst Dev Biol, Sch Life Sci, Jinan 250100, Peoples R China.
来源:Trends in Cardiovascular Medicine
出版年:2010
卷:20
期:5
页码:172-176
DOI:10.1016/j.tcm.2011.02.002
摘要:Atherosclerosis, a dynamic and progressive vascular disease arising from the combination of endothelial dysfunction and inflammation, is becoming a major killer in the 21st century. Accumulating evidence implicates phosphatidylcholine-specific phospholipase C (PC-PLC) in endothelial dysfunction and several inflammation processes. In addition, in a recent study, we demonstrated that PC-PLC contributed to the progression of atherosclerosis. Considering the important roles of PC-PLC in vascular endothelial cell dysfunction and its proinflammatory properties, we propose that a pharmacological blockade of PC-PLC represents a rational approach to atherosclerosis therapy.
收录类别:SCOPUS;SCIE
WOS核心被引频次:15
Scopus被引频次:14
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960081490&doi=10.1016%2fj.tcm.2011.02.002&partnerID=40&md5=d0b118c39a4b08298703697bf0e30397
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