标题：Effect of Obesity and Leptin Level on Migraineurs
作者：Zhang Ligong; Qin Jinjin; Chen Chunfu; Li Congcong; Diao Xiaojun
作者机构：[Zhang Ligong; Qin Jinjin; Chen Chunfu; Li Congcong; Diao Xiaojun] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250100, Shandong, Peoples R C 更多
通讯作者地址：[Chen, CF]Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250100, Shandong, Peoples R China.
来源：MEDICAL SCIENCE MONITOR
关键词：Leptin; Migraine Disorders; Obesity, Abdominal
摘要：Background: The aim of this study was to analyze the effects of obesity and leptin levels on patients with migraine, and to observe the change of leptin levels in migraineurs.; Material/ Methods: We enrolled 52 migraine patients from the Headache Clinic in Shandong Provincial Hospital into a randomized controlled trial with another 52 age-, sex-, and BMI-matched healthy subjects as controls. Leptin levels in all subjects were determined by radioimmunoassay.; Results: Compared with the control group, the migraineurs revealed no significant change in leptin levels (P>0.05). Multivariate Logistic regression analysis showed that neither abdominal obesity nor leptin had significant impact on migraine clinical features. Total body obesity had a significant effect on the frequency (OR=4.248), duration (OR= 3.167), and intensity (OR= 5.225) of the headache.; Conclusions: Total body obesity affected headache frequency, intensity, and duration, while leptin levels did not.