标题：The prognostic effects of hyponatremia and hyperchloremia on postoperative NSCLC patients
作者：Li W.; Chen X.; Wang L.; Wang Y.; Huang C.; Wang G.; Du J.
作者机构：[Li, W] Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, Department of Thoracic Surgery, Shandong 更多
通讯作者地址：[Du, J] Department of Thoracic Surgery and Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Chi 更多
来源：Current Problems in Cancer
关键词：Anion gap; Hypochloremia; Hyponatremia; NSCLC; Prognosis
摘要：Electrolytic disorders are common in lung cancer patients. But the association between serum electrolytes levels and survival in patients undergoing lung cancer resections for non–small-cell lung cancer (NSCLC) has been poorly investigated. A retrospective study was conducted on consecutive postoperative NSCLC patients. Pearson's test was used to determine the association between serum sodium and chlorine levels and clinical characteristics, and cox regression and Kaplan-Meier model were applied to analyze risk factors on overall survival. We found that hyponatremia was an independent prognostic factor associated with poor prognosis in NSCLC patients undergoing complete resection (log-rank test, P = 0.004). In addition, we found that hyperchloremia predicted a poor clinical outcome in patients with non-anion-gap (log-rank test, P = 0.011), whereas it predicted a favorable clinical outcome in patients with high-anion-gap (log-rank test, P = 0.002). The serum electrolytes levels may reflect the prognosis of NSCLC patients who receive complete resection. Early detection, monitoring, and management of hyperchloremia and hyponatremia might improve patients’ prognosis. © 2019