标题:Accelerated aging in breast cancer survivors and its association with mortality and cancer recurrence
作者:Zhu, Jingjing; Wang, Fei; Shi, Liang; Cai, Hui; Zheng, Ying; Zheng, Wei; Bao, Pingping; Shu, Xiao-Ou
作者机构:[Zhu, Jingjing; Wang, Fei; Cai, Hui; Zheng, Wei; Shu, Xiao-Ou] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt 更多
通讯作者:Shu, XO
通讯作者地址:[Shu, XO]Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 2525 West End Ave,Suite 600 IMPH, Nash 更多
来源:BREAST CANCER RESEARCH AND TREATMENT
DOI:10.1007/s10549-020-05541-5
关键词:Accelerated aging; Energy; Self-rated health; Depression; Sleep; Breast; cancer; Mortality
摘要:Purpose To prospectively investigate accelerated aging and its association with total mortality and breast cancer-specific mortality/recurrence among breast cancer survivors. Methods This study included 4218 female breast cancer patients enrolled into a population-based cohort study approximately 6-month post-diagnosis. Information on aging-related symptoms (i.e., self-rated overall health condition, energy level, depression, sleep difficulty, and quality) was collected at 18- and 36-month post-diagnosis surveys. Information on overall health, daily function impairments, survival status, and recurrence was collected at 10-year post-diagnosis survey. Record linkages with vital statistics were conducted to collect mortality information. Cox proportional hazards model was applied. Results Among 3041 10-year survivors with a mean age of 63.7 +/- 9.7 years, respectively, 52.3%, 19.0%, and 27.6% reported poor health, limitation in daily activity, and climbing floors. Age-specific prevalence revealed that breast cancer survivors reached similar prevalence of the functional limitations 5-10 years earlier than cancer-free women. At the 18-month post-diagnosis survey, respectively, 47.0%, 72.5%, and 25.1% of survivors reported unsatisfied overall health condition, reduced energy level, and depression symptoms. After a median follow-up of 10.9 years, low self-rated overall health, low energy level, and depression were significantly associated with increased total mortality, with hazard ratios (HRs; 95% confidence intervals [CI]) of 3.14 (2.43, 4.06), 1.49 (1.20, 1.84), and 1.59 (1.21, 2.09), respectively. Low self-rated health was associated with breast cancer-specific mortality/recurrence (HR 1.85, 95% CI 1.30, 2.65). No significant association was found for sleep difficulty and quality. Conclusion Aging-related physical changes/symptoms are commonly presented at 18 months after breast cancer diagnosis and are associated with worse prognosis. Impact Our findings highlight the concern of accelerated aging among breast cancer survivors.
收录类别:SCIE
资源类型:期刊论文
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