标题：The roles of integrin beta4 in vascular endothelial cells.
作者：Wang L;Dong Z;Zhang Y;Miao J
作者机构：[Wang, L] Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology, School of Life Science, Sh 更多
通讯作者地址：[Miao, JY]Shandong Univ, Sch Life Sci, Inst Dev Biol, Shandong Prov Key Lab Anim Cells & Dev Biol, Jinan 250100, Peoples R China.
来源：Journal of Cellular Physiology
摘要：Integrin heterodimers play diverse and important roles in physiological and pathological processes, such as cell adhesion, migration, proliferation, differentiation, angiogenesis, and tumor progression, via the outside-in and/or inside-out signaling pathways. Aberrant functions of integrins have been implicated in the causation and intervention of multiple diseases. Integrin beta(4), a laminin-5 (LN5) receptor, mainly locates in the adhesion structure of hemidesmosome (HD). Most of the previous researches concentrated on the role of integrin beta(4) in cancer and cancer therapy, and a few focused on the physiological roles of normal mammalian cells. Recently, accumulating data reveal that integrin beta(4) participates in cell death, macroautophagy (hereafter autophagy), senescence, and differentiation regulations in various cell types including human umbilical vein endothelial cells (HUVECs), mesenchymal stem cells, and mouse neural cells, implying the key roles of integrin beta(4) in the physiological alteration of mammalian cells. Thus, the elucidation of integrin beta(4)-mediated signaling may undoubtedly contribute to novel therapeutic strategies for various human diseases, such as vascular and neural disorders. We have reviewed the roles of integrin beta(4) in neural cells. In the present review we will discuss the recent research progress in the inherent functions and pharmacological modulation of integrin beta(4) in vascular endothelial cells.