标题：Letter regarding Wang et al. entitled \"effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: A systemic review and meta-analysis\"
作者机构：Department of Orthopaedics, Affiliated Hospital, Shandong University of Traditional Chinese;College of Basic Medical Sciences, S
通讯作者地址：[Xu, ZW]Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, Jinan 250014, Shandong, Peoples R China.
来源：Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine
摘要：Wang et al.  conducted a meta-analysis to assess the effects of murine double minute 2 (MDM2) polymorphisms on oste-osarcoma risk and survival of patients with osteosarcoma. They calculated the pooled odds ratio (OR) or hazard ratio (HR) with 95 % confidence intervals (95 % CIs) by using different effects models and concluded that MDM2 polymorphisms have some effects on the risk of osteosarcoma but have no effect on the survival of patients with osteosarcoma. Before their results can be accepted, we would like to express some concerns in relation to their meta-analysis.