标题:Association between Ghrelin Gene Variations, Body Mass Index, and Waist-to-hip Ratio in Patients with Polycystic Ovary Syndrome
作者:Xu, L.; Shi, Y.; Gu, J.; Wang, Y.; Wang, L.; You, L.; Qi, X.; Ye, Y.; Chen, Z.
作者机构:[Xu, L.; Gu, J.; Wang, Y.; Qi, X.; Ye, Y.] Qingdao Univ, Coll Med, Dept Obstet & Gynecol, Affiliated Hosp, Qingdao 266071, Peoples R China.; [Shi, Y 更多
通讯作者:Chen, Z
通讯作者地址:[Chen, Z]Shandong Univ, Prov Hosp, Ctr Reprod Med, Shandong Prov Key Lab Reprod Med, 324 Jing 5 Wei 7 Rd, Jinan 250100, Peoples R China.
来源:EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
出版年:2014
卷:122
期:3
页码:144-148
DOI:10.1055/s-0034-1367024
关键词:gene; ghrelin; polycystic ovary syndrome; single nucleotide; polymorphisms
摘要:Objective: To investigate the association between 2 single nucleotide polymorphisms (SNP501A/C and 604 G/A) in the promoter of the ghrelin gene and the hormonal and metabolic phenotypes of polycystic ovary syndrome (PCOS) in a Chinese population.; Materials and methods: 285 patients with PCOS and 260 healthy controls were selected for a prospective, case-control study at Shandong Provincial Hospital, Jinan, China. All subjects underwent genotype analysis of the 2 single nucleotide polymorphisms of the ghrelin gene. Measurements were also taken of blood lipids, glucose, and hormone levels, and calculations of body mass index (BMI) and waist-to-hip ratio (WHR) were performed to detect hormonal and metabolic phenotypes.; Results: No significant differences in polymorphism genotypes were found between PCOS patients and healthy controls. However, the frequency of the -501A/C A allele was significantly higher in the PCOS group than in the control group. PCOS -501 A/C A carriers had significantly higher BMI and WHR than PCOS women with the CC genotype. -604 G/A polymorphisms were not associated with clinical or biochemical characteristics of PCOS.; Conclusions: The -501 A/C polymorphism of the ghrelin gene is associated with metabolic features of PCOS in a Chinese population.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896455745&doi=10.1055%2fs-0034-1367024&partnerID=40&md5=3ebc3582a9112c787123eafa3f61d8d0
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