标题： Nitric oxide donor hybrid compounds as promising anticancer agents.
作者： Ding, Qin-Ge; Zang, Jie; Gao, Shuai; Gao, Qianwen; Duan, Wenwen; Li, Xiaoyang; Xu, Wenfang; Zhang, Yingjie
作者机构：[ Ding, Qin-Ge; Ding QG] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University.;[ Zang, Jie; Zang J];[ Gao, Shuai; 更多
来源： Drug discoveries & therapeutics
摘要： Nitric oxide (NO) plays important roles in cardiovascular regulation, nerve transmission delivery and immune responses. In the last semicenturry, it has been proved that though low concentration of NO is tumor-promoting, high concentration of NO could exhibit multiple antitumor effects, which led to the research and development of kinds of NO donors and NO donor hybrid compounds as antitumor agents. Herein, the recent development of NO donor hybrid compounds is briefly reviewed.