标题:Copper-catalyzed oxidative cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes
作者:Yang, Fei; Li, Yangshan; Floreancig, Paul E.; Li, Xiaoyan; Liu, Lei
作者机构:[Yang, Fei; Li, Yangshan; Li, Xiaoyan; Liu, Lei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.; [Floreancig, Paul E. 更多
通讯作者:Floreancig, Paul E
通讯作者地址:[Li, XY; Liu, L]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China;[Floreancig, PE]Univ Pittsburgh, Dept Chem, Pittsburgh, P 更多
来源:ORGANIC & BIOMOLECULAR CHEMISTRY
出版年:2018
卷:16
期:28
页码:5144-5149
DOI:10.1039/c8ob00949j
摘要:An efficient copper-catalyzed cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes mediated by DDQ has been established. A protic additive, EtOH, proved to be crucial for harmonizing the oxidation with a subsequent alkynylation step by retaining the oxidation state of an oxocarbenium ion in the form of acetal. The CDC reaction exhibits a good substrate scope, with a range of terminal aryl- and alkyl alkynes being well tolerated. The copper-catalyzed alkynylation of 2H-chromene acetals with terminal alkynes was also explored.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050356977&doi=10.1039%2fc8ob00949j&partnerID=40&md5=7e5479f4c4c328f0faa62a075ae63c75
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