标题:Long-term Impact of Temporal Sequence from Childhood Obesity to Hyperinsulinemia on Adult Metabolic Syndrome and Diabetes: The Bogalusa Heart Study
作者:Zhang, Tao; Zhang, Huijie; Li, Ying; Li, Shengxu; Fernandez, Camilo; Bazzano, Lydia; He, Jiang; Xue, Fuzhong; Chen, Wei
作者机构:[Zhang, Tao; Xue, Fuzhong] Shandong Univ, Sch Publ Hlth, Dept Biostat, Jinan, Peoples R China.; [Zhang, Tao; Zhang, Huijie; Li, Ying; Li, Shengxu; F 更多
通讯作者:Xue, FZ;Chen, W
通讯作者地址:[Xue, FZ]Shandong Univ, Sch Publ Hlth, Dept Biostat, Jinan, Peoples R China;[Chen, W]Tulane Univ, Dept Epidemiol, Sch Publ Hlth & Trop Med, New Orlean 更多
来源:SCIENTIFIC REPORTS
出版年:2017
卷:7
DOI:10.1038/srep43422
摘要:This study aims to delineate the temporal relations between body mass index (BMI) and insulin in childhood and their impact on adult metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). The longitudinal cohort consisted of 609 whites and 339 blacks who had BMI and fasting insulin measured twice in childhood (mean age = 10.5 years at baseline and 15.9 years at follow-up). Incident MetS and T2DM were identified in adulthood (mean age = 30.5 years). Cross-lagged panel and mediation analysis models were used. After adjusting for age, race, gender, and follow-up years, the cross-lagged path coefficient of BMI. insulin (beta = 0.326, p < 0.001) was significantly greater than that of insulin -> BMI (beta = -0.023, p = 0.207) in childhood, with p < 0.001 for the difference in beta s. The path coefficient for BMI -> insulin was significantly greater in MetS than in non-MetS groups (0.510 vs 0.190, p < 0.001), and greater in hyperglycemia than in normoglycemia groups (0.503 vs 0.285, p = 0.026). The mediation effect of childhood insulin on the BMI-MetS and BMI-hyperglycemia associations was estimated at 19.2% (p < 0.001) and 18.3% (p < 0.001), respectively. These findings provide evidence that higher BMI levels precede hyperinsulinemia during childhood, and this one-directional relation plays a significant role in the development of MetS and T2DM in adult life.
收录类别:SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013804426&doi=10.1038%2fsrep43422&partnerID=40&md5=3c545110cc45184aa3a63037acf7041b
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