标题：A New Route for the Synthesis of Ozagrel Hydrochloride
作者：Chenglong Yu;Baohai Zhao;Yihong Zhao
作者机构：[Yu, C] School of Chemistry and Chemical Engineering, Shandong University, Jinan, China;[ Zhao, B] School of Chemistry and Chemical Engineering, Shand 更多[Yu, C] School of Chemistry and Chemical Engineering, Shandong University, Jinan, China;[ Zhao, B] School of Chemistry and Chemical Engineering, Shandong University, Jinan, China;[ Zhao, Y] School of Chemistry and Chemical Engineering, Shandong University, Jinan, China;[ Lin, J] School of Chemistry and Chemical Engineering, Shandong University, Jinan, China 收起
来源：Organic Preparations and Procedures International: The New Journal for Organic Synthesis
出版年：2010
卷：42
期：2
页码：183-185
DOI：10.1080/00304941003699723
摘要：(E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride (ozagrel hydrochloride) is a highly selective inhibitor of thromboxane A2 (TXA2). The beneficial effects of TXA2 inhibition by ozagrel include improved motor coordination after experimental stroke and antihypertensive effects in spontaneously hypertensive rats. Since 1988, ozagrel hydrochloride has been marketed as an antithrombotic drug in Japan.1 Therefore, the development of an efficient synthetic method is of great interest.
