标题:Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors
作者:Wang, Q.;Xu, F.;Mou, J.;Zhang, J.;Shang, L.;Luan, Y.;Yuan, Y.;Liu, Y.;Li, M.;Fang, H.;Wang, B.;Xu, W.
作者机构:[Wang, Q] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, China, Department of Pharmaceutics, Sch 更多
通讯作者:Xu, WF
通讯作者地址:[Xu, WF]Shandong Univ, Sch Pharm, Dept Med Chem, Jinan 250012, Shandong, Peoples R China.
来源:Protein and peptide letters
出版年:2010
卷:17
期:7
页码:847-853
DOI:10.2174/092986610791306661
关键词:APN;Inhibitor;Lysine derivatives;Synthesis
摘要:A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC_(50) = 9.6 ± 1.3 μM) and C20 (IC_(50) = 13.6 ± 1.9 μM) were equivalent to the positive control Bestatin (IC_(50) = 11.3 ± 1.6 μM).
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954721973&doi=10.2174%2f092986610791306661&partnerID=40&md5=4949a9094c68b275d782601128a6ce9b
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