标题:Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of beta-cells in a setting of oxidative stress
作者:Li, Wenjuan; Wu, Weiwei; Song, Haibo; Wang, Fang; Li, Huanjie; Chen, Li; Lai, Yimu; Janicki, Joseph S.; Ward, Keith W.; Meyer, Colin 更多
作者机构:[Li, Wenjuan; Wu, Weiwei; Song, Haibo; Wang, Fang; Li, Huanjie; Wang, Xing Li; Tang, Dongqi; Cui, Taixing] Shandong Univ, Qilu Hosp, Key Lab Cardiovas 更多
通讯作者:Chen, L
通讯作者地址:[Chen, L]Univ S Carolina, Dept Cell Biol & Anat, Sch Med, 6439 Garners Ferry Rd, Columbia, SC 29208 USA.
来源:FEBS LETTERS
出版年:2014
卷:588
期:12
页码:2115-2124
DOI:10.1016/j.febslet.2014.04.046
关键词:Nrf2; beta-Cells; Oxidative stress; Ubiquitination; Autophagy; Diabetes
摘要:Nrf2 appears to be a critical regulator of diabetes in rodents. However, the underlying mechanisms as well as the clinical relevance of the Nrf2 signaling in human diabetes remain to be fully understood. Herein, we report that islet expression of Nrf2 is upregulated at an earlier stage of diabetes in both human and mice. Activation of Nrf2 suppresses oxidative stress and oxidative stress-induced beta-cell apoptosis while enhancing autophagic clearance in isolated rat islets. Additionally, oxidative stress per se activated autophagy in beta-cells. Thus, these results reveal that Nrf2 drives a novel antioxidant independent autophagic clearance for beta-cell protection in the setting of diabetes. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:14
Scopus被引频次:16
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901428607&doi=10.1016%2fj.febslet.2014.04.046&partnerID=40&md5=47d8cedf1df38a9afcfa35094648f208
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