标题:RETRACTED: MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma (Retracted article. See vol. 422, pg. 133, 2018)
作者:Liu, Jia; Mao, Yu; Zhang, Dakai; Hao, Shengnan; Zhang, Zicheng; Li, Zhenjiang; Li, Baosheng
作者机构:[Liu, Jia; Zhang, Dakai] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan, Peoples R China.; [Liu, Jia; Mao, Yu; Zhang, Dakai; Zhang, Zi 更多
通讯作者:Li, BC;Li, BC
通讯作者地址:[Li, BC]Shandong Acad Med Sci, Shandong Canc Hosp, Shandongs Key Lab Radiat Oncol, Dept Radiat Oncol,Chest Sect, Jinan 250117, Peoples R China;[Li, BC 更多
来源:CANCER LETTERS
出版年:2016
卷:373
期:1
页码:97-108
DOI:10.1016/j.canlet.2016.01.023
关键词:miR-143; Esophageal squamous cell carcinoma; STAT3; Progression
摘要:Although increasing evidence shows that miR-143 could act as a tumor suppressor in several cancers, little is known about the role of miR-143 in human esophageal squamous cell carcinoma (ESCC). In the present study, we found that the expression level of miR-143 is significantly reduced in clinical ESCC tissues compared with normal tissues and is correlated with lymph node metastasis (LNM), invasion and TNM stage groups. Kaplan-Meier analysis shows that miR-143 expression predicts a favorable outcome for ESCC patients. Functional experiments show that overexpression of miR-143 inhibits cell proliferation blocks the G1/S phase transition, and suppresses cell migration and invasion in vitro and in vivo. Dual luciferase assays reveal that STAT3 is a direct target gene of miR-143. Moreover, the restored expression of STAT3 protein in miR-143-overexpressing cells attenuated the suppressive effects of miR-143 on ESCC cells. Further studies verified that miR-143 repressed cell cycle and epithelial-mesenchymal transition (EMT) signaling pathways by targeting STAT3, resulting in suppressing ESCC cell proliferation, migration and invasion. We are the first to report the interaction between miR-143 and STAT3 in ESCC and in this study provide new insights into the role of miR-143 in the development of ESCC, and also implicate the potential application of miR-143 in cancer therapy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:26
Scopus被引频次:24
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958047220&doi=10.1016%2fj.canlet.2016.01.023&partnerID=40&md5=83c3e624946a5bff1b1de0783b713467
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