标题:Genome-wide association study of esophageal squamous cell carcinoma in chinese subjects identifies a susceptibility locus at PLCE1
作者:Wang L.-D.; Zhou F.-Y.; Li X.-M.; Sun L.-D.; Song X.; Jin Y.; Li J.-M.; Kong G.-Q.;等 更多
作者机构:[Wang, L.-D] Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China, Henan Key Laboratory for Esophageal Cancer Research, Departm 更多
通讯作者:Wang, LD(ldwang@xxmu.edu.cn)
通讯作者地址:[Wang, L.-D] Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China;
来源:Nature Genetics
出版年:2010
卷:42
期:9
页码:759-765
DOI:10.1038/ng.648
摘要:We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping I, 077 individuals with ESCC and 1, 733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7, 673 cases of ESCC and 11, 013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified a previously unknown susceptibility locus for ESCC: PLCE1 at 1 0q23 (pHan combined for ESCC = 7.46 X 10-56, odds ratio (OR) = 1.43; Puygur-Kazakh for ESCC = 5.70 X 10-4, OR = 1.53). We also confirmed association in 2, 766 cases of gastric cardia adenocarcinoma and the same II, 013 control subjects (PLCE1, PHan for GCA = 1.74 X 10-39, OR = 1.55). PLCE1 has important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. © 2010 Nature America, Inc. All rights reserved.
收录类别:SCOPUS
Scopus被引频次:255
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956626748&doi=10.1038%2fng.648&partnerID=40&md5=18dd84c9b62ca28da64f362db9a83167
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