标题：A screening method based on 1D CSSF-TOCSY for the identification and quantification of 11 illegal adulterants in herbal medicines
作者：Li, Fei-Fei; Guo, Chang-Chuan; Zhang, Yan-Li; Wang, Ning; Shi, Yue; Wang, Shu-Qi
作者机构：[Li, Fei-Fei; Wang, Ning; Shi, Yue; Wang, Shu-Qi] Shandong Univ, Sch Pharmaceut Sci, 44 West Wenhua Rd, Jinan 250012, Peoples R China.; [Guo, Chang- 更多
会议名称：19th Brazilian Meeting on Analytical Chemistry / 7th Iberoamerican Congress on Analytical Chemistry
会议日期：SEP 16-19, 2018
关键词：ID CSSF-TOCSY; Herbal medicinal products; Illegal adulteration
摘要：In this work, an NMR analytical procedure based on highly chemical-shift-selective filtration (CSSF) with total correlation spectroscopy (TOCSY) was used for the rapid identification and quantification of trimethoprim, benproperine phosphate, diclofenac sodium, pentoxyverine citrate, diphenhydramine hydrochloride, sulfamethoxazole, dioxopromethazine hydrochloride, chlorphenamine maleate, prednisone acetate, theophylline, and diazepam in antitussive and antiasthmatic herbal medicinal products. This method is advantageous for content determination owing to its specific background-free signals for each chemical adulterant and easy-to-perform pretreatment operations. Satisfactory results in terms of limit of quantification (0.70-1.35 mg/g), precision (relative standard deviation, RSD%: 2.05-7.08), accuracy (bias%: 0.16-6.51), and recovery (85.4%-106.5%) were achieved. Among 28 batches of antitussive and antiasthmatic herbal medicinal products, 27 batches contained illegal adulterants, which differed in terms of the amount and type of compounds. The established method was employed for the qualitative screening and quantitative detection of illegal adulterants in herbal medicinal products because of its strong selectivity and fast analysis.