标题:Tracking the Evolving Spatial-Temporal Gene Networks
作者:Gong, Weikang ;Wan, Lin
作者机构:[Gong, Weikang ] Department of Mathematics, Shandong University, Jinan; Shandong Province; 250100, China;[Wan, Lin ] NCMIS and the Key Laboratory of S 更多
来源:IFAC-PapersOnLine
出版年:2015
卷:48
期:28
页码:1365-1368
DOI:10.1016/j.ifacol.2015.12.322
关键词:gene network; modularization; module/graph matching; spatial-temporal data
摘要:The modeling and identification of the spatial-temporal gene networks in transcriptome scale is a challenging problem. To investigate the molecular mechanism of genes in a dynamic and systematic fashion, we develop a novel method for tracking the spatial-temporal modules of gene network reconstructed from the brain development gene expression data. A statistical model based method for module/graph mathch is proposed to track the evolving gene networks. We apply this method to brain spatial-temporal networks and provides new insights into the molecular mechanisms of brain development as well as the functions of the the schizophrenia associated genes. © 2015
收录类别:EI;SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988514073&doi=10.1016%2fj.ifacol.2015.12.322&partnerID=40&md5=ba9a23b63b641b82b6db99314047d296
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