标题：Roles of Chinese medicine bioactive ingredients in the regulation of cellular function of endothelial progenitor cells
作者：ZHAO Qi-Tao;LI Bao-Feng;KONG Hui
作者机构：[Zhao, Q.-T] School of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China;[ Li, B.-F] Affiliated Hospital of Sh 更多
通讯作者地址：[Zhao, QT]Shandong Univ Tradit Chinese Med, Sch Basic Med, Jinan 250355, Peoples R China.
关键词：Chinese medicine bioactive ingredients;Endothelial progenitor cells;Cardio-cerebrovascular protection;Mobilization;Apoptosis;Oxidative stress.
摘要：To improve the function of endothelial progenitor cells (EPCs) is one of the goals in Chinese traditional therapy to treat various cardio-celebrovascular diseases. In the past decades, scholars in the field of traditional Chinese medicine (TCM) have found fifteen active compounds to regulate the function of EPC. These metabolites are extracted from thirteen, plant-based Chinese medicine, with majority of them as potent reductive or oxidative hydrophilic molecules containing phenyl groups. These active compounds either enhance the mobilization of EPC, or inhibit their apoptosis through different signaling pathways. In this review, the molecular structure, biophysical properties, and the plant sources of these active ingredients and their regulatory effects on the function of EPC are summarized, aiming to reveal the modem basis of Chinese medicine for promoting blood circulation and removing blood stasis at the progenitor cell level.