标题:Associations of variants of CNR1 with obesity and obesity-related traits in Chinese women
作者:Zhuang,M.;Yang,Y.;Cao,F.;Lu,M.;Wang,X.;Zhang,J.;Chen,X.;Cheng,P.;Zhang,N.;Ye,W.;Jin,L.
作者机构:[Zhuang, M] Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China, Department of Epidemiology and Statistics 更多
通讯作者:Lu, M
通讯作者地址:[Lu, M]Shandong Univ, Clin Epidemiol Unit, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
来源:Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function
出版年:2012
卷:495
期:2
页码:194-198
DOI:10.1016/j.gene.2011.12.037
关键词:China;CNR1;Obesity;Overweight;Polymorphism;Women
摘要:The aim of this study was to investigate associations of two candidate gene SNPs of the endocannabinoid receptor type 1 gene (CNR1) with overweight, obesity and obesity-related traits in Chinese retired women. The study subjects were a subsample of the Taizhou Retiree Women Cohort, consisting of 2812 retired women aged 50-64. years recruited from Taizhou, Jiangsu, China. Neither rs2023239 nor rs806381 polymorphism was significantly associated with body mass index-defined overweight and obesity or waist-to-hip-ratio-defined obesity. For obesity-related traits, rs2023239 was significantly associated with glutamate pyruvate transaminase (GPT) (median, 18.00 vs 17.00 for TT and TC genotypes, respectively, P=0.043). The rs806381 also showed significant association with triglyceride (TG) (mean ± SD, 1.46 ± 0.20 vs 1.53 ± 0.20 for GA and GG. +. AA genotypes, respectively, P=0.013) under the dominant genetic model. In conclusion, the rs2023239 and rs806381 polymorphisms of CNR1 were not associated with increased overweight and obesity risk. But the rs2023239 polymorphism was significantly associated with GPT, and the rs806381 polymorphism was significantly associated with TG.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862804785&doi=10.1016%2fj.gene.2011.12.037&partnerID=40&md5=e06a93a52ab6365052c9427b8e0d1117
TOP