标题：Chlorambucil prodrug-participating catanionic aggregates for sustained drug release and improved antitumour activity
作者：Jiang, Yue; Hu, Xu; Zhang, Jing; Jin, Guoxia; Luan, Yuxia
作者机构：[Jiang, Yue; Hu, Xu; Zhang, Jing; Luan, Yuxia] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R Ch 更多
通讯作者：Luan, Yuxia;Luan, YX
通讯作者地址：[Luan, YX]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R China.
来源：JOURNAL OF MOLECULAR LIQUIDS
关键词：Prodrug; Catanionic aggregates; Antitumour; Sustained release;; Chlorambucil
摘要：A prodrug-participating catanionic system was developed for effective delivery of the chemotherapeutic agent chlorambucil (CLB). The catanionic aggregates were easily formed by mixing as-synthesized cationic CLB prodrug, N-(2-amino-ethyl)-4-(4-[bis-(2-chloro-ethyl)-amino]-phenyl)-butyramide (CLBM) and conventional anionic surfactant sodium bis (2-ethylhexyl) sulfosuccinate (AOT). The aggregation properties, morphology and release behaviour of the CLBM-AOT aggregates were investigated. In vitro results proved CLBM-AOT aggregates owned the significantly higher cytotoxicity and intracellular accumulation compared with the respective CLB and CLBM. The desirable sustained drug release and improved anticancer activity make CLBM-AOT aggregates a promising strategy for chemotherapy. (C) 2018 Published by Elsevier B.V.