标题:Chlorambucil prodrug-participating catanionic aggregates for sustained drug release and improved antitumour activity
作者:Jiang, Yue; Hu, Xu; Zhang, Jing; Jin, Guoxia; Luan, Yuxia
作者机构:[Jiang, Yue; Hu, Xu; Zhang, Jing; Luan, Yuxia] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R Ch 更多
通讯作者:Luan, Yuxia;Luan, YX
通讯作者地址:[Luan, YX]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R China.
来源:JOURNAL OF MOLECULAR LIQUIDS
出版年:2019
卷:274
页码:556-561
DOI:10.1016/j.molliq.2018.10.165
关键词:Prodrug; Catanionic aggregates; Antitumour; Sustained release;; Chlorambucil
摘要:A prodrug-participating catanionic system was developed for effective delivery of the chemotherapeutic agent chlorambucil (CLB). The catanionic aggregates were easily formed by mixing as-synthesized cationic CLB prodrug, N-(2-amino-ethyl)-4-(4-[bis-(2-chloro-ethyl)-amino]-phenyl)-butyramide (CLBM) and conventional anionic surfactant sodium bis (2-ethylhexyl) sulfosuccinate (AOT). The aggregation properties, morphology and release behaviour of the CLBM-AOT aggregates were investigated. In vitro results proved CLBM-AOT aggregates owned the significantly higher cytotoxicity and intracellular accumulation compared with the respective CLB and CLBM. The desirable sustained drug release and improved anticancer activity make CLBM-AOT aggregates a promising strategy for chemotherapy. (C) 2018 Published by Elsevier B.V.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056229864&doi=10.1016%2fj.molliq.2018.10.165&partnerID=40&md5=7bb5ef5fc4d2caf4d1011bdf6ff9b35d
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