标题：Potential Epigenetic-Based Therapeutic Targets for Glioma
作者：Zang, Lanlan; Kondengaden, Shukkoor Muhammed; Che, Fengyuan; Wang, Lijuan; Heng, Xueyuan
作者机构：[Zang, Lanlan; Che, Fengyuan; Wang, Lijuan] Shandong Univ, Linyi Peoples Hosp, Cent Lab, Linyi, Peoples R China.; [Zang, Lanlan; Che, Fengyuan; Wang 更多
通讯作者：Wang, LJ;Wang, LJ;Heng, XY
通讯作者地址：[Wang, LJ]Shandong Univ, Linyi Peoples Hosp, Cent Lab, Linyi, Peoples R China;[Wang, LJ]Shandong Univ, Linyi Peoples Hosp, Key Lab Neurophysiol, Linyi 更多
来源：FRONTIERS IN MOLECULAR NEUROSCIENCE
关键词：glioma; epigenetics; DNA methylation; miRNA; chromatin remodeling;; histone modifications
摘要：Glioma is characterized by a high recurrence rate, short survival times, high rates of mortality and treatment difficulties. Surgery, chemotherapy and radiation (RT) are the standard treatments, but outcomes rarely improve even after treatment. With the advancement of molecular pathology, recent studies have found that the development of glioma is closely related to various epigenetic phenomena, including DNA methylation, abnormal microRNA (miRNA), chromatin remodeling and histone modifications. Owing to the reversibility of epigenetic modifications, the proteins and genes that regulate these changes have become new targets in the treatment of glioma. In this review, we present a summary of the potential therapeutic targets of glioma and related effective treating drugs from the four aspects mentioned above. We further illustrate how epigenetic mechanisms dynamically regulate the pathogenesis and discuss the challenges of glioma treatment. Currently, among the epigenetic treatments, DNA methyltransferase (DNMT) inhibitors and histone deacetylase inhibitors (HDACIs) can be used for the treatment of tumors, either individually or in combination. In the treatment of glioma, only HDACIs remain a good option and they provide new directions for the treatment. Due to the complicated pathogenesis of glioma, epigenetic applications to glioma clinical treatment are still limited.