标题：Effect of rosuvastatin on TLR4 signal pathway in rats with cardiac hypertrophy induced by pressure overload
作者：Fan F.-F.; Zhang L.; Liang J.-J.
作者机构：[Fan, F.-F] Institute of Cardiology, Dept of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China;[ Zhang, L] Dept of Hea 更多
来源：Chinese Pharmacological Bulletin
关键词：Abdominal aortic constriction; Cardiac hypertrophy; Inflammation factors; Pressure overload; Rosuvastatin; Toll like receptor 4
摘要：Aim To study the influence of rosuvastatin on toll-like receptor 4 ( TLR4) , and its downstream nuclear transcription factor NF-kappa B p65, IkBcx , inflammation factors TNF alpha in rats with myocardial hypertrophy induced by pressure overload. Methods Myocardial hypertrophy was induced by abdominal aortic constriction ( AAC). Male Wistar rats were divided into 3 groups(n = 10) sham-operated rats(S) ;(2) AAC rats(M) ;(3) AAC + rosuvastatin(10 mg • kg-1 • d-1) rats. From 1 week pre-opertion to 4 weeks post- operation, three groups were performed by gavage administration with equal volume of rosuvastatin and vehicle. The rats underwent cardiac color Doppler examination. The level of ANP,TLR4, NF-kB p65,and TNF-α mRNA and protein expression in myocardium were detected by real-Time PCR, Western blot, immu- nohistochemical and ELISA respectively. Results The sizes of heart and cardiomyocytes and the expression of ANP mRNA and TLR4 signaling molecules were significantly increased in group M, which could be blocked by rosuvastatin. TLR4 protein was positively related to ANP, NF-kB p65 and TNF-α respectively. Conclusion Rosuvastatin prevents cardiac hypertrophy induced by pressure overload, which is associated with its inhibition of TLR4, NF-kB and TNF-ct in myocardium ex-pression.