标题：Evaluation of high-resolution susceptibility-weighted imaging in the diagnosis of cerebrovascular amyloidosis with cerebral microbleeds
作者：Su, Hui; Wu, Ke; Zhu, Xiaolin; Shi, Hao
作者机构：[Su, Hui; Wu, Ke; Zhu, Xiaolin] Taian Cent Hosp Shandong, Dept Med Imaging, Tai An 271000, Shandong, Peoples R China.; [Shi, Hao] Shandong Univ, Qia 更多
通讯作者地址：[Shi, H]Shandong Univ, Qianfoshan Hosp, Dept Med Imaging, 16766 Jingshi Rd, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
关键词：Cerebrovascular amyloidosis; cerebral microbleeds; high-resolution; susceptibility weighted imaging; magnetic resonance imaging; diagnosis
摘要：Objective: The goal of this study was to evaluate the diagnostic value of high-resolution susceptibility-weighted imaging (SWI) for cerebrovascular amyloidosis with cerebral microbleeds (CACM). Patients and methods: A total of 50 patients with CACM were enrolled and received the conventional magnetic resonance imaging (MRI) and high-resolution SWI (HR-SWI) examinations. The sensitivity, detection rate, and image quality of the two examination methods were compared. Results: A total of 105 lesions were diagnosed. The sensitivity of HR-SWI was 69.52% (73/105) and the detection rate was 96.00% (48/50), which were significantly higher than those of MRI [30.48% (32/105) and 68.00% (34/50), respectively] (P < 0.05). Furthermore, the total pass rate in the HR-SWI examination (90.00%) was significantly higher than that in MRI examination (64.00%) (P < 0.05). HR-SWI examination contributed to significantly higher ratio of high signals around the lesions [58.00% (29/50)] and lower mixed signals [6.00% (3/50)] than MRI group [4.00% (2/50) and [76.00% (38/50) respectively] (P < 0.05). HR-SWI sequences showed multiple low-signal areas with clear edges, or spot-like lesions. In MRI, T1-weighted images (T1WIs) were low signals and equisignals, which were relatively mixed, and some were manifested as ringlike, flake, and dotted T1 signals. T2Wls were mainly low and high signals, which were mixed. Conclusion: Compared with MRI, HR-SWI presented high detection rate and sensitivity in the diagnosis of CACM, and it is characterized with clear lesions as well as relatively high diagnostic value.