标题：Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
作者：Li, Jie; Fadare, Oluwole; Xiang, Li; Kong, Beihua; Zheng, Wenxin
作者机构：[Li, Jie; Xiang, Li; Kong, Beihua; Zheng, Wenxin] Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Jinan 250012, Shandong, Peoples R China.; [Li, Ji 更多
通讯作者地址：[Kong, BH]Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 W Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源：JOURNAL OF HEMATOLOGY & ONCOLOGY
关键词：Ovarian cancer; Fallopian tube; Carcinogenesis; Serous carcinoma; p53; signatures
摘要：Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications.