标题：Structure, Functions and Selective Inhibitors of HDAC6
作者：Liang, Tao; Fang, Hao
作者机构：[Liang, Tao; Fang, Hao] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Dept Med Chem, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
通讯作者地址：[Fang, H]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
来源：CURRENT TOPICS IN MEDICINAL CHEMISTRY
关键词：Epigenetics; HDAC6; Protein degradation; Neurodegenerative disease;; Cancer; HDAC6 selective inhibitors
摘要：Histone deacetylases 6 (HDAC6) has emerged as a promising target for the treatment of various human diseases including cancer, neurodegenerative disease and immunology due to its unique structure, substrate and biological functions. HDAC6 is involved in cell motility, cell survival, cell cycle progression, developmental events, prognosis as well as protein degradation and the involvement of HDAC6 in multiple biological processes has gained lots of attention. There is increasing interest in HDAC6 and its selective inhibitors. More than twenty years of synthetic efforts have developed various HDAC6 selective inhibitors with different Cap, linker and ZBG. This review will summarize recent research data regarding HDAC6 and various HDAC6 selective inhibitors.