标题:Progress in the Development of Bestatin Analogues as Aminopeptidases Inhibitors
作者:Chen, L.; Teng, Y.; Xu, W.
作者机构:[Chen, L.; Teng, Y.; Xu, W.] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.
通讯作者:Xu, W
通讯作者地址:[Xu, W]Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.
来源:CURRENT MEDICINAL CHEMISTRY
出版年:2011
卷:18
期:7
页码:964-976
DOI:10.2174/092986711794940879
关键词:Aminopeptidases; analogues; bestatin; optimization
摘要:Aminopeptidases play essential roles in protein maturation, activation, and stability as well as in the degradation and regulation of hormonal and nonhormonal peptides that can serve as important enzyme targets for drug design. This review will focus on an effective inhibitor of aminopeptidases, bestatin, including work to find better inhibitors in the past three decades that has sought to optimize bestatin and prospective developments in bestatin optimization in the future.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:8
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952803469&doi=10.2174%2f092986711794940879&partnerID=40&md5=926a0cbe9b93c7a3344ce61b0bd5b401
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