标题：Recent Advances in the Field of 16-Membered Macrolide Antibiotics
作者：W. Cui;S. Ma
作者机构：[Cui, W] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;[ Ma, S] Department of Medicin 更多
通讯作者地址：[Ma, S]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China.
来源：Mini reviews in medicinal chemistry
关键词：16-membered macrolides;structural flexibility;mycarose moiety;antimicrobial properties;resistant strains;resistance mechanism;tylosin;leucomycin.
摘要：The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.