标题:Recent Advances in the Field of 16-Membered Macrolide Antibiotics
作者:W. Cui;S. Ma
作者机构:[Cui, W] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;[ Ma, S] Department of Medicin 更多
通讯作者:Ma, S
通讯作者地址:[Ma, S]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China.
来源:Mini reviews in medicinal chemistry
出版年:2011
卷:11
期:12
页码:1009-1018
DOI:10.2174/138955711797247734
关键词:16-membered macrolides;structural flexibility;mycarose moiety;antimicrobial properties;resistant strains;resistance mechanism;tylosin;leucomycin.
摘要:The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.
收录类别:SCOPUS;SCIE
WOS核心被引频次:5
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-82955226071&doi=10.2174%2f138955711797247734&partnerID=40&md5=b13fe51559cbc3e5a0a4f541dc9ad770
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