标题：Association of Thyroid-stimulating Hormone and Cardiovascular Risk Factors
作者：Sun, Xianglan; Sun, Ying; Li, Wan-Chun; Chen, Chang-Yi; Chiu, Yen-Hui; Chien, Hung-Yu; Wang, Yao
作者机构：[Sun, Xianglan] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan, Peoples R China.; [Sun, Ying] Shandong Med Coll, Clin Dept, Jinan, People 更多
通讯作者地址：[Wang, Y]Shandong Acad Med Sci, Shandong Inst Endocrine & Metab Dis, Qingdao, Peoples R China.
关键词：thyroid-stimulating hormone; hypothyroidism; cardiovascular disease;; lipid metabolism; thyroxine
摘要：Thyroid hormone plays an important role in regulating the lipid and glucose metabolism. Previously, much attention has been drawn to define the pathophysiological relationship between thyroid dysfunction and the incidence of cardiovascular diseases (CVDs). While the conditions of overt hypothyroidism and subclinical hypothyroidism were both emphasized, the association between CVD risks and the deregulated circulating thyroid-stimulating hormone (TSH) level remains to be elucidated. Nevertheless, multiple TSH-mediated physiological adaptations, including alteration of the serum lipids, body mass index, blood pressure and insulin sensitivity, have led to the difficulty of clearly examining the association between the TSH level and CVD prevalence. The current review aims to 1) summarize the evidence for the role of thyroid dysfunction and TSH abnormality in CVD pathogenesis and 2) explore the possible underlying molecular mechanisms of TSH-mediated cardiovascular pathology in hopes of providing better therapeutic strategies for the patients with deregulated TSH.