标题：Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes
作者：Ding, Lin; Pang, Shuguang; Sun, Yongmei; Tian, Yuling; Yu, Li; Dang, Ningning
作者机构：[Ding, Lin; Pang, Shuguang; Sun, Yongmei; Tian, Yuling; Yu, Li; Dang, Ningning] Shandong Univ, Jinan Cent Hosp, Dept Endocrinol, Jinan 250013, Shandon 更多
通讯作者地址：[Pang, SG]Shandong Univ, Jinan Cent Hosp, Dept Endocrinol, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
摘要：Type 2 diabetes (T2D) is the most prevalent metabolic disease, and many people are suffering from its complications driven by hyperglycaemia and dyslipidaemia. Nuclear receptors (NRs) are ligand-inducible transcription factors that mediate changes to metabolic pathways within the body. As metabolic regulators, the farnesoid X receptor (FXR) and the liver X receptor (LXR) play key roles in the pathogenesis of T2D, which remains to be clarified in detail. Here we review the recent progress concerning the physiological and pathophysiological roles of FXRs and LXRs in the regulation of bile acid, lipid and glucose metabolism and the implications in T2D, taking into account that these two nuclear receptors are potential pharmaceutical targets for the treatment of T2D and its complications.