标题:Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: A meta-analysis
作者:Zeng,T.;Zhang,C.-L.;Han,X.-Y.;Zhao,S.;Xie,K.-Q.
作者机构:[Zeng, T] Institute of Toxicology, School of Public Health, Shandong University, 44 Wenhua West Road, Shandong Province, Jinan 250012, China;[ Zhang, 更多
通讯作者:Xie, KQ
通讯作者地址:[Xie, KQ]Shandong Univ, Sch Publ Hlth, Inst Toxicol, 44 Wenhua West Rd, Jinan 250012, Shandong, Peoples R China.
来源:European journal of gastroenterology and hepatology
出版年:2013
卷:25
期:10
页码:1183-1189
DOI:10.1097/MEG.0b013e3283612ff1
关键词:alcoholic liver disease; CD14; gene polymorphism; lipopolysaccharide;; meta-analysis
摘要:AIMS: The association between CD14-159C>T polymorphisms and alcoholic liver disease (ALD) risk has been investigated in many studies, but the results were inconsistent. Therefore, we performed a meta-analysis to investigate the association between the CD14-159C>T polymorphisms and the risk for ALD. METHODS: A comprehensive literature search was conducted to identify the relevant studies from PubMed, ISI Web of Science, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using either the fixed-effects model or random-effects model on the basis of the heterogeneity test. RESULTS: A total of eight eligible studies were included in the meta-analyses. The combined results showed no significant association between CD14-159C>T polymorphisms and ALD risk when ALD patients were compared with alcoholics without ALD (T vs. C, OR=1.22, 95% CI 0.84-1.77; TT/TC vs. CC, OR=1.43, 95% CI 0.86-2.37) and when ALD patients were compared with nonalcoholics (T vs. C, OR=1.13, 95% CI 0.90-1.43; TT/TC vs. CC, OR=1.05, 95% CI 0.76-1.46). However, a significant association was observed in the heterozygous comparison (TC vs. CC, OR=3.47, 95% CI 1.93-6.22), whereas a marginal association was observed in the dominant model (TT/CT vs. CC, OR=2.43, 95% CI 1.00-5.91) when alcoholic cirrhosis patients were compared with alcoholics without ALD. CONCLUSION: This meta-analysis suggests that the CD14-159C>T polymorphism may not be significantly associated with the risk for ALD. Although a significant association was observed between the -159C>T polymorphism and the risk for alcoholic cirrhosis, well-designed studies with large sample sizes are warranted to confirm these results.
收录类别:SCOPUS;SCIE
WOS核心被引频次:9
Scopus被引频次:10
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883653695&doi=10.1097%2fMEG.0b013e3283612ff1&partnerID=40&md5=9178f92697643e08d8295650b3546ad9
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