标题:Anti-CD11c antibody, Efalizumab attenuate ventilator-induced lung injury
作者:Pan, W. -Z.; Shi, C. -X.; Tian, M.; Yu, J. -G.
作者机构:[Pan, W. -Z.; Shi, C. -X.; Tian, M.] Qingdao Univ, Yantai Yuhuangding Hosp, Coll Med, Dept Anesthesiol, Yantai, Peoples R China.; [Yu, J. -G.] Shand 更多
通讯作者:Yu, JG
通讯作者地址:[Yu, JG]Shandong Univ, Qilu Hosp, Coll Med, Dept Anesthesiol, Jinan 250100, Peoples R China.
来源:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
出版年:2014
卷:18
期:15
页码:2182-2190
关键词:Efalizumab; Ventilator-induced lung injury; Intrapulmonary inflammatory
摘要:BACKGROUND: The pathophysiology of ventilator-induced lung injury (VILI) involves multiple mechanisms including inflammation and inflammatory cells infiltration. The anti-CD11c monoclonal antibody, Efalizumab has been demonstrated to inhibit the T cell activation, migration and adhesion to keratinocytes.; MATERIALS AND METHODS: In this study, we induced lung injury with mechanical ventilation in male Sprague-Dawley rats, the rats were divided into four groups: lung-protective ventilation (LV), injurious ventilation (HV), HV+ human IgG control and HV+ Efalizumab groups. Then we detected the lung tissue wet/dry ratio, and the activity of myeloperoxidase (MPO) was determined. The concentration of protein, TNF-a, IL-6, IL-1b and MIP-2 in the BALF were detected by ELISA. The expression ICAM-1 was measured by Realtime PCR.; RESULTS: Compared with the human IgG control treated group, the treatment of Efalizumab attenuate the ventilator-induced lung injury, including the wet/dry ratio and the activity of myeloperoxidase (MPO), meanwhile, the level of pro-inflammatory cytokines, such as TNF-a, IL-6, IL-1b and MIP-2 were decreased in the BALF of Efalizumab-treated group rats compared with the human IgG-treated control group. In addition, the histopathological index of ventilator-induced lung injury was improved after efalizumab treatment, that also reduced the recruitment of inflammatory cells into the lung, such as neutrophils.; CONCLUSIONS: Our data suggested that Efalizumab could protect rat from ventilator-induced lung injury and improve the survival time through the inhibition of intrapulmonary inflammatory response.
收录类别:SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926101727&partnerID=40&md5=b8a69b8d86fbc00065eeb7ce4033a5f0
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