标题：Preparation of minocycline hydrochloride-loaded in-situ hydrogels and effect on the periodontitis of rats
作者：Wang S.-S.; Chen X.; Du L.-N.; Jin Y.-G.; Ge C.; Sun H.-Y.; Dong B.
作者机构：[Wang, S.-S] Department of Oral Medicine, Jiamusi University, Jiamusi, 154002, China, Department of Pharmaceutical Sciences, Institute of Radiation Me 更多
通讯作者地址：[Dong, B] Department of Oral Medicine, Jiamusi UniversityChina;
来源：Journal of International Pharmaceutical Research
关键词：In-situ hydrogels; Minocycline hydrochloride; Periodontitis
摘要：Objective To evaluate the effect of minocycline hydrochloride (MH)-loaded in-situ hydrogels on periodontitis of rats. Methods Ligation, high sugar diet, local vaccination of Porphyromonas gingivalis and intramusclar injection of acetic predniso-lone were combined to establish the periodontitis of rats. Whether periodontitis was established successfully or not was determined according to clinical examination and pathology after 4 weeks. 28 periodontitis rats were divided into the model group, the positive controll (MH ointment), the blank in-situ hydrogels (ISG) and MH-loaded ISG groups. The detection index included gingival index, bleeding index, bleeding on probing, and probing depth before treatment and 4 weeks after treatment, respectively. Results The inflame-matory and destruction degrees of periodontal tissues in the positive and MH ISG groups were better than those of the model and the blank groups. Conclusion The curative effect of MH-loaded ISG on periodontitis is obvious. It is expected to become a novel formulation to treat periodontitis in future. © 2017, Editorial office of Journal of International Pharmaceutical Research. All rights reserved.