标题：AuNPs-NH2/Cu-MOF modified glassy carbon electrode as enzyme-free electrochemical sensor detecting H2O2
作者：Dang, Wenjiao ;Sun, Yanmei ;Jiao, Huan ;Xu, Ling ;Lin, Meng
作者机构：[Dang, Wenjiao ;Jiao, Huan ;Xu, Ling ] Key Laboratory of Macromolecular Science of Shaanxi Province, Shaanxi Key Laboratory for Advanced Energy Device 更多
来源：Journal of Electroanalytical Chemistry
摘要：Hydrogen peroxide (H2O2) plays an important role in physiological processes. In this work, a Cu-based metal-organic framework (Cu-MOF) was synthesized under ionothermal condition, further grafted with ammoniated Au nanoparticles (AuNPs-NH2) to prepare AuNPs-NH2/Cu-MOF composite. Glassy carbon electrode (GCE) was modified with AuNPs-NH2/Cu-MOF to prepare AuNPs-NH2/Cu-MOF/GCE electrode, which was used in H2O2 detection. AuNPs-NH2/Cu-MOF/GCE exhibits itself as a highly sensitive and selective electrochemical enzyme-free sensor for H2O2 detection. A quantitative detection to H2O2 can be found with a wide linear response toward H2O2 concentrations ranging 5–850 μM, its limit of detection (LOD) is as low as 1.2 μM with a high sensitivity of 1.71 μA/cm2·μM. AuNPs-NH2/Cu-MOF/GCE sensor has been applied to determine H2O2 effectively in human cervical cancer cells by adding the ascorbic acid as the stimulant. Our work presented a AuNPs-NH2/Cu-MOF/GCE composite electrode which is a promising enzyme-free electrochemical sensor for quantitive H2O2 detection in human cervical cancer cells.
© 2019 Elsevier B.V.