标题:Design of chitosan-based nanoformulations for efficient intracellular release of active compounds
作者:Du, Hongliang; Yang, Xiaoye; Zhai, Guangxi
作者机构:[Du, Hongliang; Yang, Xiaoye; Zhai, Guangxi] Shandong Univ, Dept Pharmaceut, Coll Pharmaceut Sci, Jinan 250012, Peoples R China.
通讯作者:Zhai, GX
通讯作者地址:[Zhai, GX]Shandong Univ, Dept Pharmaceut, Coll Pharmaceut Sci, 44 Wenhua Xilu, Jinan 250012, Peoples R China.
来源:NANOMEDICINE
出版年:2014
卷:9
期:5
页码:723-740
DOI:10.2217/NNM.14.8
关键词:chitosan nanoformulations; drug delivery; internal stimuli-responsive;; intracellular release; nondestructive pathways
摘要:The use of chitosan-based nanocarriers to transport active compounds gained an increasing attention in drug delivery. Intracellular delivery, with efficient intracellular release, become an important design considerations in chitosan based nanoformlations. Internal stimuli-responsive nanoformulations are designed to release active compounds after internalization based on certain internal stimuli like pH, redox potential and enzymes. Futhermore, nondestructive pathways may provide a nondigestive compartment for active compounds transport, which can protect the encapsulated agents from possible lysosomal degradation, thereby realizing release agents safely. This review gives a brief overview about the chitosan-based nanoformulations for efficient intracellular cargo release, including internal stimuli-responsive nanoformulations and nondestructive pathways based nanoformulations: design strategies and applications. The present problems and a possible future perspective related them are also discussed.
收录类别:SCOPUS;SCIE
WOS核心被引频次:13
Scopus被引频次:14
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901009903&doi=10.2217%2fnnm.14.8&partnerID=40&md5=c17481ff3d823fbb9a36e603b8a08054
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