标题：Design of chitosan-based nanoformulations for efficient intracellular release of active compounds
作者：Du, Hongliang; Yang, Xiaoye; Zhai, Guangxi
作者机构：[Du, Hongliang; Yang, Xiaoye; Zhai, Guangxi] Shandong Univ, Dept Pharmaceut, Coll Pharmaceut Sci, Jinan 250012, Peoples R China.
通讯作者地址：[Zhai, GX]Shandong Univ, Dept Pharmaceut, Coll Pharmaceut Sci, 44 Wenhua Xilu, Jinan 250012, Peoples R China.
关键词：chitosan nanoformulations; drug delivery; internal stimuli-responsive;; intracellular release; nondestructive pathways
摘要：The use of chitosan-based nanocarriers to transport active compounds gained an increasing attention in drug delivery. Intracellular delivery, with efficient intracellular release, become an important design considerations in chitosan based nanoformlations. Internal stimuli-responsive nanoformulations are designed to release active compounds after internalization based on certain internal stimuli like pH, redox potential and enzymes. Futhermore, nondestructive pathways may provide a nondigestive compartment for active compounds transport, which can protect the encapsulated agents from possible lysosomal degradation, thereby realizing release agents safely. This review gives a brief overview about the chitosan-based nanoformulations for efficient intracellular cargo release, including internal stimuli-responsive nanoformulations and nondestructive pathways based nanoformulations: design strategies and applications. The present problems and a possible future perspective related them are also discussed.