标题:Concurrent radiotherapy with gefitinib in elderly patients with esophageal squamous cell carcinoma: Preliminary results of a phase II study
作者:Xu, Yaping; Zheng, Yuanda; Sun, Xiaojiang; Yu, Xinmin; Gu, Jialei; Wu, Wei; Zhang, Gu; Hu, Jinlin; Sun, Wenyong; Mao, Weimin
作者机构:[Xu, Yaping] Shandong Univ, Sch Med, Jinan 250100, Peoples R China.; [Xu, Yaping; Zheng, Yuanda; Sun, Xiaojiang; Gu, Jialei] Zhejiang Canc Hosp, Dep 更多
通讯作者:Mao, WM
通讯作者地址:[Mao, WM]Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou, Zhejiang, Peoples R China.
来源:ONCOTARGET
出版年:2015
卷:6
期:35
页码:38429-38439
DOI:10.18632/oncotarget.5193
关键词:esophageal cancer; elderly patients; epidermal growth factor receptor;; gefitinib; radiotherapy
摘要:The survival rate associated with esophageal cancer is very poor due to diagnosis at advanced stages of disease and insensitivity to chemotherapy. This study investigated the efficacy of gefitinib combination with radiation in 20 elderly patients with esophageal squamous cell carcinoma (ESCC) who were not eligible for platinum-based chemotherapy. Immunohistochemistry was performed to analyze epidermal growth factor receptor (EGFR) expression, and the amplified refractory mutation system was used to detect EGFR mutations. Treatment response was assessed by endoscopy and computed tomography. Treatment toxicity was evaluated using the National Cancer Institute's Common Toxicity Criteria. The data showed that among these 20 patients, 5 experienced a complete response (CR), 13 a partial response (PR), and 2 had stable disease. The overall response rate (CR + PR) was 90%, the median overall survival (OS) was 14.0 months (95% confidence interval [ CI]: 10.0-17.9 months), and the median progression-free survival was 7.0 months (95% CI: 0-17.2 months). Patients with good Eastern Cooperative Oncology Group performance status, never smoking, and EGFR mutated tumors had the best OS (14.0, 14.0, and 17.0 months, respectively). Treatment-related grade 3/4 toxicity occurred in five patients. No case of grade 3/4 impaired liver function or hematological toxicity was observed. Concurrent radiotherapy with gefitinib is effective and tolerable in elderly ESCC patients.
收录类别:SCOPUS;SCIE
WOS核心被引频次:12
Scopus被引频次:11
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947758174&doi=10.18632%2foncotarget.5193&partnerID=40&md5=a25d603c5152664a3be81ac53f69b039
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