标题:Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal-of-Entry
作者:Ma, Juan; Li, Ruibin; Liu, Yin; Qu, Guangbo; Liu, Jing; Guo, Wenli; Song, Haoyang; Li, Xinghong; Liu, Yajun; Xia, Tian; Yan, Bing; 更多
作者机构:[Ma, Juan; Qu, Guangbo; Liu, Jing; Guo, Wenli; Song, Haoyang; Li, Xinghong; Liu, Sijin] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Envir 更多
通讯作者:Liu, Sijin
通讯作者地址:[Liu, SJ]Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China.
来源:SMALL
出版年:2017
卷:13
期:15
DOI:10.1002/smll.201603830
摘要:Although numerous toxicological studies have been performed on carbon nanotubes (CNTs), a few studies have investigated their secondary and indirect effects beyond the primary target tissues/organs. Here, a cascade of events are investigated: the initiating event and the subsequent key events necessary for the development of phenotypes, namely CNT-induced pro-inflammatory effects on iron homeostasis and red blood cell formation, which are linked to anemia of inflammation (AI). A panel of CNTs are prepared including pristine multiwall CNTs (P-MWCNTs), aminated MWCNTs (MWCNTs-NH2), polyethylene glycol MWCNTs (MWCNTs-PEG), polyethyleneimine MWCNTs (MWCNTs-PEI), and carboxylated MWCNTs (MWCNTs-COOH). It has been demonstrated that all CNT materials provoke inflammatory cytokine interleukin-6 (IL-6) production and stimulate hepcidin induction, associated with disordered iron homeostasis, irrespective of exposure routes including intratracheal, intravenous, and intraperitoneal administration. Meanwhile, PEG and COOH modifications can ameliorate the activation of IL-6-hepcidin signaling. Long-term exposure of MWCNTs results in AI and extramedullary erythropoiesis. Thus, an adverse outcome pathway is identified: MWCNT exposure leads to inflammation, hepatic hepcidin induction, and disordered iron metabolism. Together, the combined data depict the hazardous secondary toxicity of CNTs in incurring anemia through inflammatory pathway. This study will also open a new avenue for future investigations on CNT-induced indirect and secondary adverse effects.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:6
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012253707&doi=10.1002%2fsmll.201603830&partnerID=40&md5=9ad0333c44c3b38b5b8e1966af96597f
TOP