标题：Targeting the tumor promoting effects of adenosine in chronic lymphocytic leukemia
作者：Cai, Yiqing; Feng, Lili; Wang, Xin
作者机构：[Cai, Yiqing; Feng, Lili; Wang, Xin] Shandong Univ, Dept Hematol, Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.; [Wang, Xin] Sh 更多
通讯作者：Feng, LL;Wang, X
通讯作者地址：[Feng, LL; Wang, X]Shandong Univ, Dept Hematol, Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
来源：CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
关键词：Chronic lymphocytic leukemia; Tumor microenvironment; Adenosine
摘要：Chronic lymphocytic leukemia (CLL) is a hematological malignancy which is characterized by progressive accumulation of functionally deficient B cells in blood, bone marrow, and lymphatic tissue. The tumor micro environment (TME) appears to play a critical role in genesis and progression of CLL. High levels of extracellular adenosine (ADO) are detected in CLL as a consequence of expression of ecto-enzymes, such as CD39 and CD73. Extracellular ADO exhibits a broad range of effects on cell cycle control, immunoregulation, angiogenesis and cytokine regulation through both direct and indirect mechanisms. In this review, we focused on the multiple functions and related mechanisms of ADO signaling in CLL generation and progression.