标题：GDF11 Antagonizes Psoriasis-like Skin Inflammation via Suppression of NF-B Signaling Pathway
作者：Wang, Wenhan; Qu, Ruize; Wang, Xi; Zhang, Mengchen; Zhang, Yayun; Chen, Changjun; Chen, Xiaomin; Qiu, Cheng; Li, Jiayi; Pan, Xin; 更多 作者机构：[Wang, Wenhan; Wang, Xi; Zhang, Mengchen; Zhang, Yayun; Chen, Changjun; Pan, Xin; Zhao, Yunpeng] Shandong Univ, Dept Orthoped, Qilu Hosp, 107 Wenhuaxi 更多
通讯作者：Li, WW;Zhao, YP
通讯作者地址：[Li, WW; Zhao, YP]Shandong Univ, Dept Orthoped, Qilu Hosp, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
关键词：GDF11; psoriasis; inflammation; NF-B signaling pathway
摘要：Growth differentiation factor-11 (GDF11) is a key member of the transforming growth factor (TGF-) superfamily, which plays a momentous role in both normal physiological processes and pathophysiology processes. Recently, it was reported that GDF11 was closely associated with several inflammatory conditions and protected against development of inflammation. Psoriasis-like skin inflammation is a common skin inflammatory disease, yet much is unknown about the underlying mechanisms. In this study, we investigated the expression pattern of GDF11 in two psoriasis-like skin inflammation mice models and tumor necrosis factor- (TNF-)-induced RAW264.7 macrophages. Furthermore, RAW264.7 cell was cultured, and GDF11 antagonized the inflammatory function of TNF- in vitro. Moreover, imiquimod-induced mice model and IL-23-induced mice model were established to investigate the anti-inflammatory role of GDF11 in vivo. As a result, the administration of GDF11 remarkably attenuated the severity of skin inflammation in both two mice models. Additionally, the activation of nuclear NF-B (nuclear factor -light-chain-enhancer of activated B cells) signaling pathway was repressed by GDF11 treatment. Collectively, GDF11 may represent a promising molecular target for the prevention and treatment of psoriasis-like skin inflammation.