标题：Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-kappa B-Mediated Inflammation
作者：Liang, Ershun; Liu, Xue; Du, Zhanhui; Yang, Ruixue; Zhao, Yuxia
作者机构：[Liang, Ershun; Liu, Xue; Du, Zhanhui; Yang, Ruixue; Zhao, Yuxia] Shandong Univ, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 更多
通讯作者：Zhao, YX;Zhao, YX;Zhao, YX;Zhao, YX
通讯作者地址：[Zhao, YX]Shandong Univ, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China;[Zhao, YX]Shandong Un 更多
来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
摘要：Andrographolide (Andro), a major bioactive component obtained from Andrographis paniculata Nees, has exerted wide antioxidant as well as cytoprotective properties. However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) remains unknown. In this study, we evaluated the effects of Andro against diabetes-induced myocardial dysfunction and explored the underlying mechanism in STZ-induced diabetic mice. As a result, treatment with Andro dose dependently suppressed cardiac inflammation and oxidative stress, accompanied by decreasing cardiac apoptosis, which subsequently ameliorated cardiac fibrosis and cardiac hypertrophy. Further, Andro blocked hyperglycemia-triggered reactive oxygen species (ROS) generation by suppressing NADPH oxidase (NOX) activation and augmenting nuclear factor erythroid 2-related factor 2 (Nrf2) expression both in vitro and in vivo. Our results suggest that the cardioprotective effects afforded by Andro treatment involve the modulation of NOX/Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation. The present study unravels the therapeutic potential of Andro in the treatment of DCM by attenuating oxidative stress, inflammation, and apoptosis.