标题：Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer
作者：Peterson, Martha L.; Ma, Chunhong; Spear, Brett T.
作者机构：[Peterson, Martha L.; Spear, Brett T.] Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40536 USA.; [Peterson, Martha L.; Spear, Bre 更多
通讯作者地址：[Spear, BT]Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40536 USA.
来源：SEMINARS IN CANCER BIOLOGY
关键词：Alpha-fetoprotein; Hepatocellular carcinoma; Transcription; Liver;; Development; Mouse
摘要：The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer. (C) 2011 Elsevier Ltd. All rights reserved.